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Secondary Hemostasis – The Intrinsic Pathway
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Secondary Hemostasis – The Intrinsic Pathway
Exposure to contact substances, such as collagen, can activate the intrinsic pathway.
The exposed collagen is the location where a complex between High Molecular Weight Kininogen (HMWK), Prekallikrein (also known as Fletcher Factor, which activates to Kallikrein), and factor XII (Hageman Factor) forms.
Together, this three biochemical complex, adhered to the collagen binding site, catalyzes the conversion of factor XII to its activated form, XIIa, thereby triggering the intrinsic pathway.
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