Variations in White Cell Morphology -- Granulocytes (Online Course)

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Authors: Marjorie A. Spahn, MT (ASCP); Barbara Minderman, MT (ASCP)
Reviewer: Leah Coppolino, MPH, CLS(NCA), MT(ASCP)

This course covers all aspects of white blood cell morphology, including identifying changes in morphology in granulocytes. Addresses barr bodies, Dohle bodies, Auer rods, vacuoles, hypersegmented granulocytes, and hyposegmented granulocytes. Excellent as a refresher or for clinical laboratory science students.

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Continuing Education Credits

P.A.C.E.® Contact Hours: 2 hour(s)
Florida Board of Clinical Laboratory Science CE - General (Hematology): 2 hour(s)

Objectives

Explain the importance of identifying changes in granulocyte morphology.
Define, describe, and explain the relationship of Barr bodies to abnormal morphology.
Discuss nuclear hypersegmentation and hyposegmentation, with respect to: definition, appearance, composition, and significance.
Discuss nuclear hypersegmentation and hyposegmentation, with respect to: hypersegmented granulocytes and hyposegmented granulocytes.
Identify each of the following cytoplasmic variations: Dohle bodies, Auer rods, vacuoles, and abnormal granulation.

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Course Outline

Introduction

Variations in Morphology
Importance of Recognition
Match the following:

Nuclear Variations

Hypersegmentation
Conditions Associated with Hypersegmented Neutrophils
Hypersegmented Neutrophils
Hypersegmented Neutrophils (cont.)
A Normally Segmented Neutrophil
Which of the following statements is true for hypersegmented neutrophils? (Choose ALL of the correct answers)
Hyposegmentation
Conditions Associated with Hyposegmented Neutrophils
Pelger-Huet Anomaly
Normal Band Forms vs. Pelger-Huet Bands
Bilobed Neutrophil
Pelger-Huet Cells
Single-Lobed Pelger-Huet Cells
Which of the following are seen in Pelger-Huet anomaly?
Barr Body
Which of the following best describes a Barr body?

Cytoplasmic Variations

Döhle Bodies
Döhle Bodies, continued
Toxic Granulation
Toxic Granulation and Vacuolation
Cytoplasmic Vacuolation
Neutrophil with Normal Granulation
Toxic granulation is seen most frequently in:
Auer Rods
Auer Rods, continued
Which of the following inclusions may be seen in the cytoplasm of myeloblasts?
Auer rods are significant when they are seen in the cytoplasm of blast cells because they are diagnostic for:
Chediak-Higashi Anomaly
Albinism and Chediak-Higashi Anomaly
Chediak-Higashi Anomaly vs. Toxic Granulation
Chediak-Higashi Anomaly Inclusions
Chediak-Higashi anomaly is characterized by which of the following?
May-Hegglin Anomaly
Alder Anomaly (Alder-Reilly Anomaly )
Alder Anomaly, continued
Alder anomaly inclusions may be found in which of the following white blood cell types?
Which of the following inclusions has a similar appearance on a Wright's stained smear to a Döhle body?
The inclusions that are frequently seen on the same peripheral blood smear with toxic granulation include: (Choose ALL that apply)
What type of inclusions are present in the cell that is indicated by the arrow?
The cell in this image is typical of other neutrophils on this peripheral blood smear from a patient with sepsis. Which morphologic term describes the...

References

References

Additional Information

Level of instruction: Intermediate

Intended Audience: clinical laboratory science students, medical technologists, and medical laboratory technicians seeking review or continuing education. It is also appropriate for medical students, pathology residents, and pathologists.

Course Description: This course covers morphologic variations observed in granulocytes, including nuclear and cytoplasmic variations.

Authors: by Marjorie A. Spahn, MT (ASCP); Barbara Minderman, MT (ASCP), updated by EMHP, and adapted for the web by Paul Fekete, M.D. C.A.P AP/CP.

Reviewer: Leah Coppolino, MPH, CLS(NCA), MT(ASCP) is the Director of the Clinical Laboratory Science Program at St. Christopher’s Hospital for Children in Philadelphia, Pennsylvania. She holds a Masters in Public Health from Thomas Jefferson University.

About the Course: This course is part of a series of courses adapted for the web by MediaLab, under license from Education Materials for Health Professionals, Inc. Dayton OH, 45420. Copyright EMHP. This course was reviewed and revised in 2012.

Variations in White Cell Morphology -- Granulocytes Keywords

These are the most common topics and keywords covered in Variations in White Cell Morphology -- Granulocytes:

gargoylism leukemia myeloblast autosomal hypersegmentation white cell morphology cytoplasm morphologic lymphoblastic basophil auer rod wright may-hegglin endoplasmic pathological myeloid hyposegmented neutrophil chromosome physician diagnostic hypersegmented bilobed nonpathological platelet granules identification granulation nuclear body hypersegmented neutrophil hyposegmentation digestion morphological azurophilic virus chemotherapy metastasized syndrome autodigestion blood parachromatin alder-reilly reactive abnormal lymphoblast drug stimulus cytoplasmic barr bodies protein band neutrophil nucleus tumor eosinophil morphology barr body cytoplasmic vacuolation dohle bodies albinism bacterial monocyte hyposegmented lymphocyte phagocytosis disease toxic chromatin diagnosis pelger-huet vacuoles dna dohle body reticulum treatment granulocyte inclusion thrombocytopenia malignant deficiency bacteria chediak-higashi pyknotic vacuole lysosomes infection electron

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