HER2 Protein Overexpression and Gene Amplification

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HER2 Protein Overexpression and Gene Amplification

The HER2 protein is overexpressed in 20-30% of breast cancers. Overexpression is often the result of gene amplification and is associated with poor prognosis in breast cancer patients. Patients with overexpression are eligible for therapy with the monoclonal antibody trastuzumab, known as Herceptin®, which may be used as a treatment in HER2 amplified breast cancer.