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Coagulation Disorders - Inherited
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Coagulation Disorders - Inherited
Von Willebrands Disease
is a platelet disorder.
This disorder is characterized by a functional defect in Von Willebrands factor (vWF) itself.
This disease often clinically manifests with a concurrent deficiency of factor VIII, but will present with a normal platelet count.
As far as genetics and inheritance, both men and women are affected equally.
Von Willebrands factor is essential for platelet binding, therefore, a defect in vWF causes impaired platelet adhesion and aggegration.
The treatment of Von Willebrands Disease involves the administration cryoprecipitate, as it is rich in vWF.
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