Coagulation Disorders - Inherited

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Coagulation Disorders - Inherited

  • Inherited disorders are those which are considered to be inborn, and have some familial linkage.
  • Hemophilia A is a deficiency of coagulation factor VIII.
    • It is important to note that Hemophilia A can also be acquired, versus inherited, in cases where patients produce auto-antibodies against factor VIII.
  • It is the most commonly encountered hereditary based coagulation disorder.
  • Found more commonly in males, its pattern of inheritance is sex-linked recessive.
  • This disorder presents clinically with hemorrhagic events ranging in severity from mild to severe. Patients often present with spontaneous bleeding into their joints, a classic symptom of this affliction.
  • The treatment of Hemophilia A often involves the administration of commercial factor VIII products.