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Secondary Hemostasis – The Extrinsic Pathway
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Secondary Hemostasis – The Extrinsic Pathway
It should be noted that this pathway is sometimes referred to as the Tissue Factor Pathway.
Once a vessel has been breached, tissue factor is exposed to circulating factor VII, and the two substances bind to form a complex.
The newly formed tissue factor/factor VII complex is thought to be the primary physiological stimulus for blood coagulation.
In other words, more hemostatic activities are initiated by the extrinsic pathway than the intrinsic.
This complex leads to the activation of factor VII (factor VIIa) which is now ready to catalyze the conversion of factor X to factor Xa as part of the common pathway.
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