An Introduction to the Fundamentals of Coagulation

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An Introduction to the Fundamentals of Coagulation

  • The ability to control bleeding hinges primarily on the availability of both platelets and coagulation factors, as well as their adequate functionality.

  • It is important to note, however, that there are limits in the size, or the degree of damage that can be controlled and repaired without outside (medical) intervention.

  • As one may expect, and the prior chart illustrates, damage to a larger vessel yields a more substantial bleed, and in turn consumes a greater quantity of coagulation components.

  • These variables can radically alter the effectiveness of hemostatic control mechanisms.