The appearance of an antibody post-transfusion is a sign of a delayed transfusion reaction. Only when there is evidence of increased red cell destruction is the reaction termed a delayed hemolytic reaction. Appearance of an antibody without cell destruction is a delayed serologic reaction.
Alloimmunization
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- DAT, eluate if positive
- Antibody screen
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Alloimmunization to HLA antigens
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- Platelet antibody screen
- Lymphocytotoxicity testing
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Delayed hemolytic
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- DAT, eluate if positive
- Antibody screen
- Other tests for hemolysis
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Transfusion-associated graft-vs-host disease
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- HLA typing
- Cytogenetic analysis
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Infectious disease transmission
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- Specific testing for antigens or antibodies associated with the disease
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Iron overload
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- Serum ferritin
- Liver enzymes
- Endocrine function tests
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Post-transfusion purpura
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- Platelet antibody screen/identification
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