An Introduction to the Fundamentals of Hemostasis

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An Introduction to the Fundamentals of Hemostasis

  • The ability of the body to maintain a state of homeostasis, or physiological equilibrium, is absolutely essential for the effective, efficient functionality of all body systems.

  • The mechanisms involved in blood coagulation, also known as hemostasis or blood clotting, serve to illustrate this concept.

  • Hemostasis is the process that leads to the cessation of bleeding from a blood vessel. Regarding blood flow, we maintain homeostasis through this process.

  • With the maintenance of homeostasis in mind, it is vital that the body be able to rapidly repair vascular damage, arresting blood flow in the process while simultaneously maintaining blood in a fluid state within the vascular compartment.
  • Blood flow is arrested by way of a complex series of interrelated physiological and biochemical processes.
  • There are a wide variety of factors that influence the effectiveness of hemostatic processes, including the following:

    • Type and degree of vessel damage
    • Ability of vasoconstriction to occur
    • Availability of platelets & their functionality
    • Availability of clotting factors & their functionality
    • Absence of inhibitors & anticoagulants