Ghost Cells

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The page below is a sample from the LabCE course The Urine Microscopic: Microscopic Analysis of Urine Sediment. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Ghost Cells

If RBCs become swollen in dilute urine to the point that the cell membrane ruptures, the cell loses its hemoglobin so that only the membrane and free hemoglobin remain. These empty membranes are known as "ghost" cells.

Phase-contrast microscopy enhances the appearance of the red cell membrane on ghost cells. If the membrane can be visualized, the cell would be counted as an RBC. A positive blood result on the reagent dipstick would also help to confirm them as RBCs.