Trichrome stains are used to distinguish collagen from muscle and aid in the diagnosis of fibrotic changes, such as those that occur in liver cirrhosis and renal disease. For this reason, Masson's Trichrome is often performed routinely on liver and kidney biopsies. Masson's Trichrome is also used to differentiate tumors that have originated from muscle cells from those that have developed from fibroblasts.
