Signs and Symptoms of HH

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The page below is a sample from the LabCE course Hereditary Hemochromatosis. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Signs and Symptoms of HH

Most patients with HH become symptomatic during middle age. Early signs and symptoms of HH are vague, nonspecific, and variable. As iron overload progresses (late HH), signs and symptoms become more severe and are related to damage of specific organs.
Table 1 lists the signs and symptoms of Early HH compared to Late HH disease.
Table 1. Signs and Symptoms of Hereditary Hemochromatosis.
Early Signs & Symptoms of HHLate Signs & Symptoms of HH
Fatigue Gray or bronze skin tone
Depression Cirrhosis of the liver
Irritability Liver cancer
Joint Pain Heart disease or heart failure
Impotence Diabetes mellitus
Amenorrhea Hypopituitarism

Hypogonadism
Joint disease

Chronic abdominal pain
Severe fatigue

Increased incidence of bacterial infection
Splenomegaly