From the choices below, select all the reasons Rh antibodies are clinically significant.

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More than one answer is correct. Please select all correct answers

	The antibodies are IgG immunoglobulins.
	The antibodies are capable of crossing the placenta.
	The antigens in the blood group system are well-developed early in the life of the fetus.
	The antibodies are composed of a pentameter of immunoglobulins.