Red Blood Cell (RBC) Morphology (Online Course)

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Authors: Martha MacPherson, R.T. and Marjorie A. Spahn, MT (ASCP)
Reviewers: Paul Fekete, MD, FCAP; Barbara Cebulski, MS, MLS(ASCP)

All major aspects of red cell morphology are reviewed in this richly illustrated interactive course that uses numerous photomicrographs to identify and heighten study of morphologic abnormalities in red cell size, shape, and color. This course is ideal for review by techs and students and use in continuing education and cross training.

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Continuing Education Credits

Objectives

  • Discuss the procedure for proper red blood cell examination with respect to:
    • objective(s) used
    • area examined
  • Discuss various aspects of red cell morphology related to cell size
  • Discuss various aspects of red cell morphology related to cell color.
  • Discuss various aspects of red cell morphology related to cell shape.

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Course Outline

  • Introduction to Red Cell Morphology
      • Red Blood Cell (RBC) Morphology
      • Assessing RBC Morphology: Area of Evaluation
      • Normal RBCs
      • Abnormal RBCs
      • Artifactual Morphology
      • Which of the following are reasons for evaluating red cell morphology as part of the differential procedure?
      • Match the following red blood cell (RBC) observations with the area of the peripheral blood smear that is being observed.
  • Red Cell Characteristics Related to Size
      • MCV and Anisocytosis
      • Normal RBC Size
      • Microcyte
      • Microcyte with Normal Hemoglobin Content
      • Macrocyte
      • Another Example of Macrocytosis
      • The red blood cells indicated by the arrows have diameters greater than 9 µm and decreased central pallor. How would you report these cells?
      • Which of the following statements can be made about the red blood cells (RBCs) that are seen in the image on the right?
  • Red Cell Characteristics Related to Color
      • Hemoglobin Concentration
      • Normochromic Red Cells
      • Hypochromia and Hyperchromia
      • Hypochromia
      • Polychromatophilic Red Blood Cells
      • How would you characterize the red blood cells (RBCs) in the image on the right?
      • How would you characterize the RBCs in this image?
      • What type of cells are indicated by the arrows in this slide?
  • Red Cell Characteristics Related to Shape
      • Poikilocytosis
      • Red Cell Variations in Shape
      • Acanthocytes
      • Acanthocytes, continued
      • Target Cells (Codocytes)
      • Target Cells, continued
      • Teardrop Cells (Dacrocytes)
      • Teardrop Cells, continued
      • Sickle Cells (Drepanocytes)
      • Sickle Cells, continued
      • Burr Cells (Echinocytes)
      • Elliptocytes (Ovalocytes)
      • Elliptocytes, continued
      • Fragmented Red Blood Cells
      • Prekeratocytes or Blister Cells
      • Keratocytes
      • Keratocytes, continued
      • Spherocytes
      • Conditions Associated with Spherocytes
      • Stomatocytes
      • Stomatocytes, continued
      • Summary
      • What type of red cells are indicated by the arrows in this image?
      • What are the abnormal red blood cells that are indicated by the arrows in this image?
      • What are the abnormal red cells indicated by the arrows in this field?
      • What are the cells that are indicated by the arrows in this field?
      • What is the predominant abnormal forms seen in this slide?
      • What are the abnormal cells that are indicated by the arrows in this image?
  • Red Cell Characteristics Related to Cell Arrangement
      • Rouleaux and Autoagglutinaton
      • True Rouleaux
      • Artifactual Rouleaux
      • Autoagglutination
      • Another Example of Autoagglutination
      • How would you describe the arrangement of RBCs on this slide?
      • How would you describe the arrangement of RBCs on this slide?
      • How would you describe the arrangement of RBCs on this slide?
  • References
      • References

Additional Information

This course describes in detail the morphology of RBCs and their morphological variations in regards to size, shape, and color.

Intended Audience: This course is suitable for clinical laboratory scientists, MT and MLT students, medical students and pathology residents.

Level of Instruction: Basic 

Author Credentials: This course was developed by by Martha MacPherson, R.T. and Marjorie A. Spahn, MT (ASCP), and was updated by Education Materials for Health Professionals, Inc., under the supervision of Marjorie Spahn MT(ASCP). It was adapted for online use by Paul Fekete, MD, FCAP, the President and CEO of MediaLab, Inc. Current review and revision by Barbara Cebulski, MS, MLS(ASCP)
Copyright: Copyright EMHP Inc.,Dayton OH. Licensed to MediaLab Inc., Dacula, GA. Web-based version produced solely by MediaLab Inc.




hypochromic red cells


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elliptocytes 2


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