Immune Hemolytic Anemias (Online Course)

(based on 512 customer ratings)

Author: Erin Tretter, MBA, MT(ASCP)
Reviewer: Christine Christopher, MT(ASCP)SBB

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Continuing Education Credits

  • P.A.C.E.® Contact Hours: 2 hour(s)
  • Florida Board of Clinical Laboratory Science CE - General (Blood Banking / Immunohematology): 2 hour(s)

Objectives

  • Compare the different types of immune hemolytic anemias.
  • Identify and investigate potential serologic discrepancies caused by autoimmune and drug-induced hemolytic anemias.
  • Differentiate the four mechanisms involved in drug-induced hemolytic anemias.
  • List medications that may be associated with drug-induced hemolytic anemia.

Customer Ratings

(based on 512 customer ratings)

Course Outline

  • Immune Hemolytic Anemias
      • Introduction
      • Direct Antiglobulin Test (DAT)
      • Classification of Hemolytic Anemias
  • Alloimmune Hemolytic Anemia
      • Alloimmune Hemolytic Anemia
  • Autoimmune Hemolytic Anemias
      • Autoimmune Hemolytic Anemia (AIHA): Introduction
      • Symptoms of Autoimmune Hemolytic Anemias
      • Testing for Autoantibodies
      • Possible Serological and Laboratory Presentations
      • True or False: A direct antiglobulin test (DAT) is usually negative in cases of autoimmune hemolytic anemia.
    • Cold Autoimmune Hemolytic Anemia
      • Cold Autoimmune Hemolytic Anemia
      • Cold Hemagglutinin Disease (CHD)
      • Paroxysmal Cold Hemoglobinuria (PCH)
      • PCH Donath-Landsteiner Test
      • ABO/Rh Typing in the Presence of Cold Autoantibodies
      • Laboratory Presentations of Cold Autoantibodies - Antibody ID and Detection
      • In paroxysmal cold hemoglobinuria (PCH), the autoantibody specificity is most commonly anti-I.
      • Cold hemagglutinin disease (CHD) is caused by an IgM antibody with a broad thermal range.
    • Warm Autoimmune Hemolytic Anemia
      • Warm Autoimmune Hemolytic Anemia (WAIHA)
      • Serological Characteristics in WAIHA
      • WAIHA Investigation: Serological Findings Following Elution
      • Possible Scenarios When Transfusions are Needed in the Presence of WAIHA
      • Detection and Identification of An Alloantibody in the Presence of a Warm-Reactive Autoantibody
      • Autologous Adsorption (Autoadsorption)
      • Allogeneic Adsorption
      • Transfusion Considerations for WAIHA
      • Treatment of WAIHA
      • In a case of WAIHA , the production of IgG or IgG and complement that sensitizes the red blood cells leads to red blood cell destruction.
      • Which type of adsorption must be done if a patient has been recently transfused?
    • Mixed-Type Autoimmune Hemolytic Anemia
      • Mixed Type Autoimmune Hemolytic Anemia (AIHA)
  • Drug-Induced Hemolytic Anemia
      • Drug-Induced Immune Hemolytic Anemia Introduction
      • Mechanisms
      • Drug Adsorption Mechanism
      • Immune Complex Mechanism
      • Non-Immune Adsorption of Proteins
      • Induction of Autoimmunity
      • Treatment of Drug-Induced Immune Hemolytic Anemia
      • Laboratory Investigation of Drug-Induced Immune Hemolytic Anemia
      • Which mechanism of drug-induced red cell destruction closely mimics the serologic presentation of warm autoimmune hemolytic anemia (WAIHA)?
      • Which mechanism of drug-induced hemolytic anemia involves the formation of drug-antibody combinations that bind non-specifically to RBC membranes and ...
      • Penicillin is one of the medications that may be responsible for the immune-complex mechanism of drug-induced hemolytic anemia.
  • Case Study
      • Case Study OneA 50-year-old female patient with systemic lupus erythematosus (SLE) is admitted to the hospital with evidence of hemolysis, including d...
      • Case Study One, continued
      • Case Study One, continued
      • Case Study One, continued
      • Case Study One, continuedTo determine the appropriate adsorption technique to use, an accurate transfusion history must be obtained. In this case the ...
      • Case Study One, continued The results of the autoadsorbed serum tested with a set of antibody screen cells are shown on the right. What does the patte...
      • Case Study One Conclusion
  • Case Study
      • Case Study Two
      • Case Study Two, continued
      • Case Study Two, continuedA DAT is ordered on the patient along with an antibody screen. The DAT is positive and the antibody screen is negative. Eluti...
      • Case Study Two, Conclusion
  • References
      • References

Additional Information

Author information: Erin Tretter, MBA, MT(ASCP), is currently the Rapid Response Laboratory Supervisor at Paoli Hospital. Erin received her Masters in Business Administration from Florida Institute of Technology where she is a member of the Phi Kappa Phi Honor’s Society. She received her BS in Medical Technology from California University of Pennsylvania and has experience as a Generalist, including Blood Bank, Hematology and Chemistry. Erin is currently the Blood Bank Clinical Instructor for the Clinical Laboratory Science Program at St. Christopher’s Hospital for Children and has 7 years experience teaching immunohematology concepts and laboratory procedures to laboratory science students. She has also taught Blood Bank in the Clinical Laboratory Technician program at the Community College of Philadelphia.
Reviewer information: Christine Christopher, MT(ASCP)SBB has over 25 years of experience as a Medical Technologist. She holds a Bachelors degree in Medical Technology from Northern Illinois University and Certification as a Specialist in Blood Bank. She has been employed by Central Dupage Hospital in Winfield, IL as a Medical Technologist and by the College of American Pathologists as an Inspection Specialist in the Laboratory Accreditation Program and as a Technical Assessor for the CAP 15189 ISO program.
 

Immune Hemolytic Anemias Keywords

These are the most common topics and keywords covered in Immune Hemolytic Anemias:

clinical cells newborn aiha intravascular anti-c3 erythematosus identification autoadsorptions hemagglutinin incubation bilirubin drug-treated immune-mediated reticulocyte non-reactive anti-igg mononucleosis philadelphia transfusion warmer fails disease phenotype hemoglobin davis non-specifically autologous contains blood hemoglobinemia anemias autoimmune drug-adsorption autoadsorption rbcs transfusions demonstrable laboratory autoimmunity warm-reactive info autoantibodies serum infectious bethesda adsorbed controls harvested hemolysis drug-induced antigen-antibody reagents diagnosis adsorb body autoantibody high-dose serologic alloantibodies hemolytic drug-antidrug donor considerations symptoms anti-i titer alloantibody autocontrol hemolysin globulin anemia medicine specificity allogeneic adsorptions antibodies penicillin anti-p immunoglobulins intravenous autoadsorbed discrepancies polychromatophilic blood bank procedures antibody cold-reactive hemoglobinuria serological hematocrit reactive treatment donath-landsteiner specificities waiha polyspecific elution non-self agglutination infection paroxysmal non-immune medication antihuman transfused lupus blood banking drug button plasma vitro rudmann red blood cell antiglobulin sensitizes monospecific transfuse harmening pathologic phenotypes antigen-negative indistinguishable jaundice proceeding saline antigen eluate adsorption red blood cells saunders erythrocyte amplitude modern biphasic antigens crossmatches immune



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Protein Adsorption


Donath Landsteiner Test


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