Fever, Hives and Other Woes: A Review of Transfusion Reactions (by CACMLE) (Online Course)

Kelly E. Capocelli, MD, Medical Director - Transfusion Medicine Services, Children's Hospital Colorado

See all available courses »

Continuing Education Credits

Objectives

  • Describe the clinical signs and symptoms associated with the various types of transfusion reactions.
  • Define the differences between immune-mediated and nonimmune-mediated reactions.
  • Identify the steps involved in a comprehensive laboratory investigation of a transfusion reaction.

Course Outline

  • PowerPoint Slides
      • Fever, Hives and Other Woes: A Review of Transfusion Reactions
      • Learning Objectives
      • Case 1
      • Case 1: Transfusion Vitals
      • Case 1: Transfusion Reaction Laboratory Work-up
      • Case 1: Differential Diagnosis
      • Underlying Medical Condition
      • Immune-Mediated Acute Hemolytic Transfusion Reaction
      • Immune-Mediated Acute Hemolytic Transfusion Reaction, cont.
      • Acute Hemolytic Transfusion Reactions
      • Acute Hemolytic Transfusion Reactions, cont.
      • Nonimmune-Mediated Causes of Acute Hemolytic Transfusion Reactions
      • Transfusion-Related Sepsis
      • Transfusion-Related Sepsis, cont.
      • Transfusion-Related Acute Lung Injury (TRALI)
      • Blood Products Implicated in TRALI
      • Causes of TRALI
      • Two-Hit Hypothesis
      • Two-Hit Hypothesis Illustration
      • Chest X-Ray and Histology Results
      • Investigation of Suspected TRALI
      • Sample Worksheet for TRALI Work-up
      • Febrile Non-Hemolytic Transfusion Reaction
      • Febrile Non-Hemolytic Transfusion Reaction, cont.
      • Febrile Non-Hemolytic Transfusion Reaction, cont.
      • Case 1: Diagnosis
      • Case 1: Diagnosis - FNHTR
      • Febrile Transfusion Reaction Algorithm
      • Next Case . . . .
      • Case 2
      • Case 2 - Transfusion Vitals
      • Case 2 - Transfusion Reaction Laboratory Work-up
      • Case 2 - Differential Diagnosis
      • Case 2 - TRALI?
      • Transfusion-Associated Circulatory Overload (TACO)
      • Transfusion-Associated Circulatory Overload (TACO), cont.
      • Allergic Reactions
      • IgE-Mediated Allergic Reactions
      • Mild Allergic Reactions
      • Mild Allergic Reactions, cont.
      • Anaphylactic Reactions to Blood Products
      • IgA Deficiency
      • Clinical Definition of IgA Deficiency
      • Pathophysiology of IgA Deficiency
      • Blockage Schematic
      • Medications Associated with IgA Deficiency
      • IgA-Deficient Plasma Products
      • Non-IgE-Mediated Causes of Allergic Reaction
      • Case 2: Diagnosis
      • Case 2: Diagnosis - Major allergic transfusion reaction
      • Next case . . . .
      • Case 3
      • Case 3, cont.
      • Case 3: Differential Diagnosis
      • Transfusion-Associated Graft-vs-Host Disease
      • Transfusion-Associated Graft-vs-Host Disease, cont.
      • Delayed Hemolytic Transfusion Reaction
      • Delayed Hemolytic Transfusion Reaction, cont.
      • Delayed Hemolytic Transfusion Reaction, cont.
      • Delayed Hemolytic Transfusion Reaction - Treatment
      • Back to the case . . . .
      • Case 3: Retrospective Lab Review
      • Case 3: Diagnosis?
      • Case 3: Diagnosis - Delayed Hemolytic Transfusion Reaction
      • Case 3 Diagnosis: Delayed Hemolytic Transfusion Reaction, cont.
      • Summary
      • Nonimmune-Mediated Causes of Transfusion Reactions
      • Immune-Mediated Causes of Transfusion Reactions
      • Standard Laboratory Investigation of Transfusion Reactions
      • Specialized Laboratory Investigations for Selected Reactions
      • Specialized Laboratory Investigations for Selected Reactions, cont.
      • Most Important Intervention
      • The End



Slide 1


Slide 5


Slide 41


19


22