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Titer Information and Courses from MediaLab, Inc.

These are the MediaLab courses that cover Titer and links to relevant pages within the course.

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Laboratories Individuals

CLIA Blood Banking Review
Anti-Rho immune serum is administered to:View Page
A secondary immune response is generally associated with which of the following antibodies:View Page

CLIA General Laboratory Review
The prozone effect ( when performing a screening titer) is most likely to result in:View Page
The term TITER ( as it applies to the measurement of antibodies) is best defined as:View Page
Choose the correct result (titer) given the following test results:View Page
Which of the following would be considered most significant as it relates to serological testing:View Page

CLIA Microbiology / Serology Review
The disk diffusion method of measuring antimicrobial sensitivity is also termed:View Page
Which one of the following tests should be used to monitor a patient's response to treatment for syphilis:View Page
Which two of the following tests are helpful for documenting previous Streptococcal throat and skin infections:View Page

Introduction to the ABO Blood Group System
ABO Antibodies and Aging

ABO antibodies are not usually produced by an infant until 3 to 6 months of age. Antibodies found in the sera of newborns are almost always IgG, passively acquired from the mother. Thus, serum testing of newborns is not performed. Anti-A and anti-B titers are highest at ages 5-10 years and then they gradually decrease. Thus, in elderly patients, ABO antibodies may be difficult to detect. In patients with hypogammaglobulinemia, some leukemias, lymphomas or patients who are taking immunosuppressive drugs, the expected antibodies may be weak or even absent, reflecting the low levels of gamma globulin in the patient’s serum. As previously mentioned, these and other ABO typing discrepancies must be resolved before true ABO type can be determined.

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"Immune" ABO Antibodies

A person exposed to a specific immunizing event may produce “immune” ABO antibodies of the same specificity as the “naturally” occurring antibody, but with different biological behavior. Such immunizing events include pregnancy with an ABO incompatible fetus or transfusion of ABO incompatible red cells. After immunization, the subject’s antibody may increase in titer and/or avidity, develop powerful hemolyzing properties, or become more active at 37ºC.

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Mycology: Yeasts and Dimorphic Pathogens
Of the following responses, the one observation that would rule out cryptococcosis as the cause of meningoencephalitis is:View Page

Red Cell Morphology
Autoagglutination

Autoagglutination is seen in this slide, as evidenced by cells clumping together rather than stacked like coins. Autoagglutination is caused by the presence of antibody in the plasma. High titers of antibody are needed for the demonstration of autoagglutination on a Wright’s stained smear.

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