T-lymphocyte Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover T-lymphocyte and links to relevant pages within the course.
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| Pluripotential stem cells are capable of producing which of the following: | View Page |
| What is another name used to designate a fully committed B-lymphocyte: | View Page |
| Proteins Involved in Adsorption The joining of the HIV and the host cell involves a spike on the HIV envelope and a CD4 molecule on the T-lymphocyte, macrophage, or brain cell.The molecule on the HIV spike is called glycoprotein 120 or gp120. The "120" refers to the molecular weight of the glycoprotein.While the CD4 site is important in viral binding, there is evidence that there are other molecules called co-receptors also involved.These molecules are embedded in the membranes of T-lymphocytes, macrophages, and brain cells. In the T-lymphocyte the abbreviated name of the protein molecule is CXCR4. | View Page |
| Which of the following is NOT a possible cause of cell death after HIV infection? | View Page |
| Proteins Involved in Adsorption The joining of the HIV and the host cell involves a spike on the HIV envelope and a CD4 molecule on the T-lymphocyte, macrophage, or brain cell.The molecule on the HIV spike is called glycoprotein 120 or gp120. The "120" refers to the molecular weight of the glycoprotein.While the CD4 site is important in viral binding, there is evidence that there are other molecules called co-receptors also involved.These molecules are embedded in the membranes of T-lymphocytes, macrophages, and brain cells. In the T-lymphocyte the abbreviated name of the protein molecule is CXCR4. | View Page |
| Adsorption (1) While more research is needed to confirm the sequence, it is believed that the gp120 molecule on the HIV unites, via the V3 loop, with the CD4 molecule on the T-lymphocyte, macrophage, or brain cell.The gp120 then changes shape, drops down, and binds with the co-receptor.Thus HIV binds twice to the T-lymphocyte or macrophage - once at the CD4 molecule and once at the co-receptor site. | View Page |
| Infection of the Host Cell (2) The DNA provirus continues to encode new HIV particles within the host cell. During this early stage the injured host cells, such as T-lymphocytes, are able to replace themselves, and the body remains able to launch a defensive response. Eventually, though, the number of viruses becomes overwhelming. | View Page |
| Destruction of the Host Cell The mechanism of host cell destruction remains under investigation, but three possibilities have been proposed:Viral budding tears a hole in the host cell's membrane, causing cytoplasmic leakage.The supply of useful T-lymphocytes is depleted, resulting from the formation of huge, functionless syncytia.Some mechanisms cause the provirus to provoke the synthesis of a large number of new HIV particles, causing the rapid depletion of cellular components and with it the destruction of the cell. | View Page |