Staphylococcal Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Staphylococcal and links to relevant pages within the course.
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| Review 1 Francois P. Vaudaux P. Foster TJ. Lew DP.:
Host-bacteria interactions in foreign body infections.
Infection Control & Hospital Epidemiology. 17:514-20, 1996Persistent staphylococcal infections are a major medical problem, especially when they occur on implanted materials or intravascular catheters.This review describes some of the recently discovered molecular mechanisms of Staphylococcus aureus attachment to host proteins coating biomedical implants.These interactions involve specific surface proteins, called bacterial adhesins, that recognize specific domains of host proteins deposited on indwelling devices, such as fibronectin, fibrinogen, or fibrin.Elucidation of molecular mechanisms of S. aureus adhesion to the different host proteins may lead to the development of specific inhibitors blocking attachment of S. aureus, which may decrease the risk of bacterial colonization of indwelling devices. | View Page |
| Review 3 Ladhani S. Joannou CL. Lochrie DP. Evans RW. Poston SM.:
Clinical, microbial, and biochemical aspects of the exfoliative toxins causing staphylococcal scalded-skin syndrome.
Clinical Microbiology Reviews. 12:224-242, 1999The exfoliative (epidermolytic) toxins of Staphylococcus aureus are the causative agents of the staphylococcal scalded-skin syndrome (SSSS), a blistering skin disorder that predominantly affects children. Clinical features of SSSS vary along a spectrum, ranging from a few localized blisters to generalized exfoliation covering almost the entire body.The toxins act specifically at the zona granulosa of the epidermis to produce the characteristic exfoliation, although the mechanism by which this is achieved is still poorly understood.Despite the availability of antibiotics, SSSS carries a significant mortality rate, particularly among neonates with secondary complications of epidermal loss and among adults with underlying diseases. | View Page |
| Decreasing the risk of staphylococcal colonization of indwelling catheters in the future may involve: | View Page |
| The staphylococcal toxins causing the scalded skin syndrome (SSSS) have as their site of action in which of the following layers of skin: | View Page |