Spherocyte Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Spherocyte and links to relevant pages within the course.
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|This is a representative field from the patient's peripheral blood smear.What RBC morphology is prominent on this patient's smear?||View Page|
|The red cells in this illustration exhibit which of the following abnormal erythrocyte shapes:||View Page|
|Spherocytes are associated with which two of the following conditions:||View Page|
|An increase in the osmotic fragility of erythrocytes is indicative of:||View Page|
|Case continued:Which hematologic condition could be associated with the findings shown in these images?||View Page|
|What are the abnormal red blood cells that are indicated by the arrows in this peripheral blood smear image?||View Page|
|What are the cells that are indicated by the arrows in this peripheral blood smear image?||View Page|
Another example of a knizocyte is seen in this slide. These forms are seen in conditions in which spherocytes are visible and in some types of hemolytic anemia.
|Conditions Associated with Spherocytes|
Examples of conditions in which spherocytes can be seen include hereditary spherocytosis and immune hemolytic anemias (i.e., ABO incompatibility). Spherocytes can also form in conditions where there has been a direct physical or chemical injury to the cells. An example would be a smear from an individual who has suffered severe burns. In hereditary spherocytosis, a condition where spherocytes are numerous, the MCHC value will be at the upper limits of normal, or about 36. The identification of spherocytes on the smear of a patient with hereditary spherocytosis can aid significantly in the diagnosis of the disorder. Artifactual spherocytes can appear when blood is stored for a prolonged period of time.
|The identification of which of the following abnormal forms may contribute significantly to specific clinical diagnosis:||View Page|
|The predominant forms of abnormal morphology seen in this slide are:||View Page|
|What are the abnormal cells that are indicated by the arrows in this image?||View Page|
A spherocyte can also be seen in this field.
Spherocytes are red cells that have a decreased surface-to-volume ratio. As a result, this type of cell is denser than a normal red cell and on a Wright's stained smear, in the proper viewing area, they appear to be round, darkly-stained cells without central pallor. Two spherocytes are indicated by the arrows on this peripheral blood smear image.
|The cell in the center of this slide is an example of a:||View Page|