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Spherocyte Information and Courses from MediaLab, Inc.

These are the MediaLab courses that cover Spherocyte and links to relevant pages within the course.

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Beta Thalassemia
This is a representative field from the patient's peripheral blood smear.What RBC morphology is prominent on this patient's smear?View Page

Hematology / Hemostasis Question Bank - Review Mode (no CE)
The red cells in this illustration exhibit which of the following abnormal erythrocyte shapes:View Page
Spherocytes are associated with which two of the following conditions:View Page
An increase in the osmotic fragility of erythrocytes is indicative of:View Page

Red Cell Disorders: Peripheral Blood Clues to Nonneoplastic Conditions
Case continued:Which hematologic condition could be associated with the findings shown in these images?View Page

Red Cell Morphology
What are the abnormal red blood cells that are indicated by the arrows in this peripheral blood smear image?View Page
What are the cells that are indicated by the arrows in this peripheral blood smear image?View Page
Another Knizocyte

Another example of a knizocyte is seen in this slide. These forms are seen in conditions in which spherocytes are visible and in some types of hemolytic anemia.

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Conditions Associated with Spherocytes

Examples of conditions in which spherocytes can be seen include hereditary spherocytosis and immune hemolytic anemias (i.e., ABO incompatibility). Spherocytes can also form in conditions where there has been a direct physical or chemical injury to the cells. An example would be a smear from an individual who has suffered severe burns. In hereditary spherocytosis, a condition where spherocytes are numerous, the MCHC value will be at the upper limits of normal, or about 36. The identification of spherocytes on the smear of a patient with hereditary spherocytosis can aid significantly in the diagnosis of the disorder. Artifactual spherocytes can appear when blood is stored for a prolonged period of time.

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The identification of which of the following abnormal forms may contribute significantly to specific clinical diagnosis:View Page
The predominant forms of abnormal morphology seen in this slide are:View Page
What are the abnormal cells that are indicated by the arrows in this image?View Page
Another Spherocyte

A spherocyte can also be seen in this field.

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Spherocytes are red cells that have a decreased surface-to-volume ratio. As a result, this type of cell is denser than a normal red cell and on a Wright's stained smear, in the proper viewing area, they appear to be round, darkly-stained cells without central pallor. Two spherocytes are indicated by the arrows on this peripheral blood smear image.

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The cell in the center of this slide is an example of a:View Page

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