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Lymphocytes "transform" in response to antigenic stimuli. As discussed earlier, their nuclei becomes larger with more open chromatin and a greater degree of nuclear folding. The cytoplasm becomes abundant, the number of azurophilic granules may be increased and vacuoles may be present. The cytoplasmic membrane may be easily indented by surrounding red blood cells, resulting in a scalloped appearance of the cell's outer edge. Again, these lymphocytes may also be referred to as reactive or atypical lymphocytes.