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Destruction of the Host Cell
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HIV: Structure and Replication (retired 2/20/2013)
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Learn more about HIV: Structure and Replication (retired 2/20/2013) (online CE course)
Destruction of the Host Cell
The mechanism of host cell destruction remains under investigation, but three possibilities have been proposed:
Viral budding tears a hole in the host cell's membrane, causing cytoplasmic leakage.
The supply of useful T-lymphocytes is depleted, resulting from the formation of huge, functionless syncytia.
Some mechanisms cause the provirus to provoke the synthesis of a large number of new HIV particles, causing the rapid depletion of cellular components and with it the destruction of the cell.
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