White Blood Cell Disorders and Platelets:: 2. Leukocytosis Case Study

Pelger-Huet Anomaly

  • The Pelger-Huet anomaly is a congenitally acquired condition of nuclear segmentation and is clinically insignificant. There is no loss of cellular function.
  • The condition can be suspected if typical bilobed, "pince-nez" nuclei are observed (left upper frame in the composite photograph).
  • Band neutrophils usually have two distinct lobes, connected by a relatively short but thick bridge as illustrated in the upper and lower right frames.
  • Monolobated cells may also be encountered, as illustrated in the lower left frame. If these are seen in significant numbers, the possibility of a homozygous Pelger-Huet should be considered.

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