Doehle Bodies: Review from White Cell and Platelet Disorders: Peripheral Blood Clues to Nonneoplastic Conditions, presented by MediaLab

White Blood Cell Disorders and Platelets:: 4. Intra-cytoplasmic Inclusion Bodies

Doehle Bodies: Review

Doehle bodies are discrete, round or oval aggregates at the cytoplasmic periphery of neutrophils (blue arrows in figures).
They stain sky blue with Romanowsky's stain and often may be deceivingly inconspicuous.
In electron-micrographs, Doehle bodies are recognized as lamellar aggregates of rough endoplasmic reticulum.
Although not considered a marker for leukemia, Goudsmit, et al (Brit J Hematol 20:447-562, 1971)reported their presence in family members, 2 sisters and 3 brothers. Two of the brothers died of acute myeloblastic leukemia.
These testimonials indicate that Doehle bodies, when identified in peripheral blood smears, should be taken seriously so as to stimulate a clinical investigation of the patient.

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