White Blood Cell Disorders and Platelets:: Peripheral Smear Review Introduction

Criteria for requesting a hematologist's review of the smear.

The following are suggested guidelines directed toward white blood cell data necessitating a hematologist's review:

  • Total white blood cell count <3000/cumm or >12,000/cumm
  • Neutrophils >85%
  • Lymphocytes >43% or <10%
  • Monocytes >8%
  • Eosinophils >6%
  • Basophils >4%,.
  • Mixed cells >8% on a 3-part automated differential
  • A morphology review may also be indicated if the platelet count is <100,000/cumm or >650,000/cumm.

    Thus, if the granulated cells illustrated in the photograph exceed 6% of the total WBC on a five-part differential or, in combination with monoctytes and basophils, exceed 8% of the total WBC on a three-part differential, a flag would alert the operator that a morphology review or manual differential is needed.

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