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Rouleaux and Agglutination
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Red Cell Disorders: Peripheral Blood Clues to Nonneoplastic Conditions (retired 5/26/2022)
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Learn more about Red Cell Disorders: Peripheral Blood Clues to Nonneoplastic Conditions (retired 5/26/2022) (online CE course)
Rouleaux and Agglutination
Cell Type
Image
Cellular Description
Associated Diseases and Conditions
Rouleaux
Red blood cells (RBCs) appear as "stacked coins."
Cells overlap each other.
Stacked-coin morphology is noted throughout the peripheral blood smear.
Conditions associated with increased concentrations of globulins and/or fibrinogen
Hyperparaproteinemias
Waldenstrom macroglobulinemia
Multiple myeloma
Chronic inflammatory disorders
Agglutination
Clusters of RBCs due to antigen/antibody reactions in vivio
Cannot distinguish the outlines of individual RBCs
Cold agglutinins (most often IgM antibodies)
Paroxysmal cold hemoglobinuria
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