Eosinophils vs. Neutrophils
Eosinophils (see arrow) have a larger, more 3-dimensional granule compared to neutrophils. In peripheral blood smears, eosinophils are normally bi-lobed. In cytospins this does not necessarily hold true and should not be used solely to differentiate an eosinophil from a neutrophil.
In a well stained smear, the orange color of eosinophil granules is easily observed which easily distinguishes the eosinophils from neutrophils. However, when the slide is not stained appropriately, observing the granule size will aid in their identification.
