This sample is demonstrating an anti-golgi pattern.
Whenever you read an ANA the first step is to see if there is a clearly discernable pattern in the nucleus of the interphase cells. In this case the answer is no (a). However, there is a discernable pattern staining in the cytoplasm. This coarse granular staining cap like staining on one side of the cytoplasm is characteristic of anti-golgi antibodies and should be reported (b).
This sample is reported as ANA Negative, suspect anti-golgi antibodies present. No follow-up testing is necessary. Anti-golgi antibodies are seen in various diseases.
Golgi Autoantibodies
- 7 different antigens identified
Cytoplasmic pattern
- Coarse granular staining around one side of nucleus
Report as
Clinical significance
- Sjögren's syndrome, SLE, RA
- Viral infections: HIV, EBV, CMV and rubella
