Cytoplasmic Variations

Alder-Reilly Anomaly (Alder's Anomaly)

  • Alder Reilly Anomaly is a rare autosomal recessive hereditary disorder in which the basic defect involves protein-carbohydrate complexes called mucopolysaccharides. The accumulation of partially degraded (broken down) protein-carbohydrate complexes within the lysosomes account for the larger than normal purple-staining granules seen in the granulocytes, monocytes and/or lymphocytes.

  • The granules may occur in clusters, rather than diffusely, throughout the cytoplasm as in toxic granulation.

  • These inclusions may be seen in the bone marrow more frequently than in peripheral blood. The physical characteristics associated with this disorder include gargoylism and dwarfism.

  • The function of the cells involved is not affected.

  • This morpholical change would be classified as pathological since the body is responding abnormally even though the function is not affected.

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