Granules in Chediak-Higashi Syndrome versus Toxic Granulation from Variations in White Cell Morphology

Cytoplasmic Variations

Granules in Chediak-Higashi Syndrome versus Toxic Granulation

The neutrophils found in Chediak-Higashi can be differentiated from toxic granulation.
In conditions causing toxic granulation, the granules are smaller and more numerous and only the neutrophils are affected.
In Chediak-Higashi, eosinophils, basophils, lymphocytes and monocytes are affected. In eosinophils larger than normal eosinophilic granules may be seen, basophils may exhibit larger than normal basophilic granules, lymphocytes, large azurophilic granules. Larger pale granules/bodies may appear in monocytes.

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