The presence of hyposegmented neutrophils can be an acquired phenomenon, as a result of severe infection, burns, malignancy, chemotherapy or other drugs such as sulfonamides. When the causative agent has been removed, the cells will return to normal. Percentages of neutrophils affected will vary in this condition. Hyposegmented neutrophils as an aquired phenomenon are known as pseudo-Pelger-Huet cells. These are considered pathological.