Clinically, beta thalassemia intermedia is midway in severity between major and minor. Growth and development in children with this disorder can usually be considered normal and most patients have a normal life span. However, they can demonstrate some facial bone deformity and splenomegaly.

Transfusions (again with iron-chelating agents) may be used as a supportive therapy.

This form of beta thalassemia is most common in eastern Mediterranean countries.