Case Study: Immune Alloantibody

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The page below is a sample from the LabCE course Antibody Detection and Identification (retired 12/6/2013). Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Case Study: Immune Alloantibody

A 42-year-old male received 6 units of RBCs during open heart surgery 6 months ago. His antibody screen was negative at that time. He has returned for a follow up surgery and his antibody screen is now positive with both screen cells at the AHG phase.

Reactions are occurring at AHG phase, which indicates a possible clinically significant antibody, Jka showing dosage.
Refer to Case Study 1 panel below to see reactions of antibody panel.
IS = Immediate Spin; AHG = Antihuman Globulin Phase; CC = Check Cells; AC = Auto Control; ND= Not done
Case study 1 conclusion:
Patient's previous transfusion 6 months ago exposed him to the Jka antigen, causing the formation of this antibody, which is known for showing dosage.