Anemia is moderate.
RBC count is increased.
Hb is moderately decreased.
MCV is decreased.
MCHC is decreased.
RDW is increased.
RBC morphology shows slight hypochromic microcytosis with codocytes, schizocytes, and basophilic stippling.
Reticulocytes are moderately increased.
Hb electrophoresis demonstrates abnormal patterns in both adults and neonates.
Adults:

HbA decreased
HbA2 decreased
HbF normal to decreased
Hb H -2-40% (beta chain tetramers)

Neonates: 10-40% Bart's (gamma chain tetramers)
Hb H inclusions are frequently seen.
Bone marrow demonstrates erythroid hyperplasia.