Defining Thalassemia

Anemia in Alpha Thalassemia

  • In thalassemia there is often an excess production or accumulation of globin chains produced by genes that are not effected by the thalassemia deletion.
  • In alpha thalassemia this may be seen as gamma chain tetramers (hemoglobin Bart's) in the unborn child and as beta chain tetramers (hemoglobin H) in adults.
  • Tetramer accumulation often leads to red blood cell damage and hemolytic anemia.

Earn ASCLS P.A.C.E.® credits for your state clinical laboratory personnel license. Visit LabCE.com for laboratory continuing education.

Alpha Thalassemia course details »

Learn more about laboratory continuing education for ASCP, AMT, NCA, and state renewal and recertification requirements »

Get information on OSHA laboratory safety courses for clinical and medical laboratories »