Appearance of Mononuclear Cells

Large Lymphocytes

  • Large lymphocytes have abundant pale blue transparent cytoplasm.
  • If you imagine putting a printed page behind the cell, the cytoplasm looks as though you could see through it to read the words.
  • Although there are usually no cytoplasmic granules present, a few large well-defined azurophilic granules (lysozomes) can occasionally be seen.

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