Enzyme Abnormalities and Drugs

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Enzyme Abnormalities and Drugs

The following is a list of enzymes for which known mutations have been associated with clinical effects.

Enzymes

Substrates (Drugs)
Acetylaldehyde dehydrogenase Alcohol

Acetylcholinesterase

 Succinylcholine
Alcohol dehydrogenase Alcohol
Dihydropyrimidine dehydrogenase Fluorouracil
CYP2C9 Warfarin, phenytoin, losartan
CYP2C19 Diazepam, omeprazole (Prilosec)
CYP2D6 Many antidepressants, opioids, antiarrhythmics
Glucose-6-phosphate dehydrogenase Aspirin, quinidine
N-acetyltransferase Procainamide, isoniazid
Thioprine methyltransferase 6-mercaptopurine
UDP-glucuronosyl transferase Acetaminophen, tolbutamide, irinotecan