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Review 1
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The page below is a sample from the LabCE course
Case Studies in Clinical Microbiology
. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.
Learn more about Case Studies in Clinical Microbiology (online CE course)
Review 1
Francois P. Vaudaux P. Foster TJ. Lew DP.: Host-bacteria interactions in foreign body infections.
Infection Control & Hospital Epidemiology. 17:514-20, 1996
Persistent staphylococcal infections are a major medical problem, especially when they occur on implanted materials or intravascular catheters.
This review describes some of the recently discovered molecular mechanisms of
Staphylococcus aureus
attachment to host proteins coating biomedical implants.
These interactions involve specific surface proteins, called bacterial adhesins, that recognize specific domains of host proteins deposited on indwelling devices, such as fibronectin, fibrinogen, or fibrin.
Elucidation of molecular mechanisms of
S. aureus
adhesion to the different host proteins may lead to the development of specific inhibitors blocking attachment of
S. aureus
, which may decrease the risk of bacterial colonization of indwelling devices.
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