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Review 1
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The page below is a sample from the LabCE course
Case Studies in Clinical Microbiology
. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.
Learn more about Case Studies in Clinical Microbiology (online CE course)
Review 1
Podschun R. Ullmann U.: Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors
Clinical Microbiology Reviews. 11(4):589-603, 1998
Bacteria belonging to the genus
Klebsiella
frequently cause human nosocomial infections. In particular, the medically most important Klebsiella species,
Klebsiella pneumoniae
, accounts for a significant proportion of hospital-acquired urinary tract infections, pneumonia, septicemias, and soft tissue infections.
The principal pathogenic reservoirs for transmission of
Klebsiella
are the gastrointestinal tract and the hands of hospital personnel. Because of their ability to spread rapidly in the hospital environment, these bacteria tend to cause nosocomial outbreaks. Hospital outbreaks of multidrug-resistant
Klebsiella
species, especially those in neonatal wards, are often caused by new types of strains, the so-called extended-spectrum-beta-lactamase (ESBL) producers
The incidence of ESBL-producing strains among clinical
Klebsiella
isolates has been steadily increasing over the past years. The resulting limitations on the therapeutic options demand new measures for the management of
Klebsiella
hospital infections.
While the different typing methods are useful epidemiological tools for infection control, recent findings about
Klebsiella
virulence factors have provided new insights into the pathogenic strategies of these bacteria.
Klebsiella
pathogenicity factors such as capsules or lipopolysaccharides are presently considered to be promising candidates for vaccination efforts that may serve as immunological infection control measures.
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