Erythrocyte Disorders: Smear Case 10: Multiple Erythrocyte Abnormalities

Howell -Jolly bodies/ other erythrocyte environmental alterations

Several erythrocyte abnormalities are present in both the upper and lower photomicrographs. Many of these atypical cells are probably present as a result of the patient's splenectomy.

  • Considerable anisocytosis and poikilocytosis with many tear-drop cells, bite cells, fragmented forms, and a few target cells are apparent.
  • Some of the erythrocytes in the upper frame contain Howell-Jolly bodies (DNA fragments) that may be single or multiple, especially in myeloproliferative disorders. These inclusions stain negatively for iron and are eccentrically placed in the red cell cytoplasm.

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