An Introduction to the Fundamentals of Coagulation: The Fibrinolytic System

The Fibrinolytic System

  • Fibrin strands woven into the clot structure are cleaved into soluble fibrin fragments, and then removed by macrophages.
  • The action of fibrinolysis also serves to restore blood flow into the area that had been sealed off, helping to promote further healing.
  • Fibrinolysis is mediated by a proteolytic enzyme called plasmin.
  • Plasminogen is the inactive precursor form of plasmin that is found in plasma.
  • Plasmin takes on fibrinolytic properties after activation, digesting both fibrin and fibrinogen.
  • Inhibitors act to control the process, serving as a check and balance system for fibrinolytic activities.



Meet OSHA laboratory safety and compliance requirements with over 40 online courses for clinical laboratories. Learn more.

Fundamentals of Hemostasis course details »

Learn more about laboratory continuing education for ASCP, AMT, NCA, and state renewal and recertification requirements »

Get information on laboratory safety and compliance courses for clinical and medical laboratories »