An Introduction to the Fundamentals of Coagulation: Overview of Secondary Hemostasis

Secondary Hemostasis – The Intrinsic Pathway

  • Here is where the “cascade” or “waterfall” nomenclature becomes evident as each activated factor triggers the conversion and activation of subsequent factors.

  • Factor XIIa, activated previously, catalyzes the conversion of factor XI into XIa, while in the presence of HMWK.

  • Note: This reaction can occur without HMWK, but will be much slower.


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