Subscriber Login   Users   Administrators
Integrated cloud-based solutions for clinical laboratories

Sample Page

The page below is a sample from the MediaLab course, Introduction to the ABO Blood Group System.

Learn about Compliance & CE courses available for clinical laboratories and individual medical technologists.

The H gene

Three separate loci (ABO, Hh, and Se) contain the genes that control the location and occurrence of the A and B antigens. Hh and Se genes are closely linked on chromosome 19. The precursor substance is acted upon by the H gene and is converted to H substance. The product of the H gene is an enzyme fucosyltransferase, responsible for attaching fucose to the terminal galactose of the precursor substance on the RBC membrane and thus forming H substance. There are only two recognized alleles at this locus: the active form, H, and an amorph, h. The H gene is a high-incidence gene. People who inherit hh are extremely rare. Since the h gene is amorphic, it does not act on the precursor substance.



MediaLab, Inc.    |    (877) 776-8460 (tollfree)    |