Background and Introduction to the ABO System

Question

Why does agglutination (clumping) sometimes occur when red cells from one individual are mixed with serum from another?

Please select the single best answer

Antigens in one person's serum may react with antibodies on the other person's RBCs.
Antibodies in one person's serum may react with antigens on the other person's RBCs.
The individuals may have different immunologic histories.

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