Siderotic Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Siderotic and links to relevant pages within the course.
Learn more about laboratory continuing education for medical technologists to earn CE credit for AMT, ASCP, NCA, and state license renewal and recertification. Or get information about laboratory safety and compliance courses that deliver cost-effective OSHA safety training and continuing education to your laboratory's employees.
| Siderotic Granules To verify that red cell inclusions contain iron, it is necessary to use an iron stain, such as Perl's Prussian blue. The iron-containing granules are called siderotic granules. A mature erythrocyte containing siderotic granules is referred to as a siderocyte, while an immature (nucleated) erythrocyte containing siderotic granules is known as a sideroblast. A Pappenheimer body is a siderotic granule which is visible on Wright stain. All Pappenheimer bodies are Prussian blue positive, but not all siderotic granules are visible on Wright's stain as Pappenheimer bodies.
| View Page |
| Siderocytes and Ring Sideroblasts. 20 to 60% of red cell precursors seen in bone marrow slides normally contain siderotic iron granules visible with Prussian Blue stain. The presence of sideroblasts and siderocytes indicates that the red cell precursors have an ample supply of iron. When a red cell precursor contains too much iron, the siderotic granules form a ring around the nucleus and the resulting cells are referred to as ring sideroblasts. The ring sideroblast is an abnormal (pathological) form of sideroblast.
| View Page |