Siderocyte Information and Courses from MediaLab, Inc.

These are the MediaLab courses that cover Siderocyte and links to relevant pages within the course.

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Erythrocyte Inclusions - Wright Stained Smears
This Prussian blue stained smear shows siderocytes.	View Page
This Prussian blue stained smear shows both sideroblasts and siderocytes.	View Page
Match the following terms with the correct definition.	View Page
Siderocytes This slide is stained with Perls' Prussian blue. Three siderocytes containing blue granules are indicated by arrows. These inclusions may or may not have been visible on Wright's stain, as Pappenheimer bodies.	View Page
Sideroblast A sideroblast, shown at the arrow, is a nucleated red cell containing siderotic granules. However, these granules are generally not clustered around the nucleus, but are found in the periphery of the cell. Siderocytes are present normal bone marrow.	View Page
Ring Sideroblast A nucleated red cell containing siderotic granules clustered around the nucleus is shown by the arrow. This is called a ring sideroblast and is seen only in pathological conditions. A siderocyte is also present toward the lower left.	View Page
This Prussian blue stained smear shows:	View Page
Siderotic Granules To verify that red cell inclusions contain iron, it is necessary to use an iron stain, such as Perl's Prussian blue. The iron-containing granules are called siderotic granules. A mature erythrocyte containing siderotic granules is referred to as a siderocyte, while an immature (nucleated) erythrocyte containing siderotic granules is known as a sideroblast. A Pappenheimer body is a siderotic granule which is visible on Wright stain. All Pappenheimer bodies are Prussian blue positive, but not all siderotic granules are visible on Wright's stain as Pappenheimer bodies.	View Page
Which of the following is considered a pathological finding?	View Page
Siderotic Granules This slide has been stained with Perls' Prussian blue stain. The siderotic granules present in some of the red cells are stained blue-green, indicating its iron composition. These cells are called siderocytes.	View Page
Siderocytes and Ring Sideroblasts. 20 to 60% of red cell precursors seen in bone marrow slides normally contain siderotic iron granules visible with Prussian Blue stain. The presence of sideroblasts and siderocytes indicates that the red cell precursors have an ample supply of iron. When a red cell precursor contains too much iron, the siderotic granules form a ring around the nucleus and the resulting cells are referred to as ring sideroblasts. The ring sideroblast is an abnormal (pathological) form of sideroblast.	View Page
In which of the following conditions are Pappenheimer bodies and siderocytes seen on the peripheral smear?	View Page

Red Cell Disorders: Peripheral Blood Clues to Nonneoplastic Conditions
The red cell inclusions in this split frame photomicrograph of peripheral smears are called:	View Page