Quinidine Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Quinidine and links to relevant pages within the course.
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| Drug-induced thrombocytopenia Some drugs may cause thrombocytopenia in a small number of patients that take them. Drugs that have been implicated in development of thrombocytopenia include heparin, quinidine, quinine, and sulfonamides, among others. Thrombocytopenia is most likely the result of an antibody forming against the drug. This antibody binds to a glycoprotein on the platelet and then the platelet is taken out of circulation by the reticuloendothelial (RE) system. The platelet count will rise once the drug is discontinued. | View Page |
| TDM for Cardiac Medications Inotropics (drugs used to increase the pumping ability of the heart) and antiarrhythmics may need TDM. The cardiac glycoside inotropics digoxin and digitoxin have narrow therapeutic windows. Overdose can cause vomiting, diarrhea, confusion, visual disturbances, and cardiac arryhthmias. Examples of cardiac medications that are monitored by TDM include: Digoxin Digitoxin Procainamide N-Acetylprocainamide (NAPA) -the metabolite of procainamide Quinidine | View Page |
| Enzyme Abnormalities and Drugs The following is a list of enzymes for which known mutations have been associated with clinical effects. Enzymes Substrates (Drugs) Acetylaldehyde dehydrogenase Alcohol Acetylcholinesterase Succinylcholine Alcohol dehydrogenase Alcohol Dihydropyrimidine dehydrogenase Fluorouracil CYP2C9 Warfarin, phenytoin, losartan CYP2C19 Diazepam, omeprazole (Prilosec) CYP2D6 Many antidepressants, opioids, antiarrhythmics Glucose-6-phosphate dehydrogenase Aspirin, quinidine N-acetyltransferase Procainamide, isoniazid Thioprine methyltransferase 6-mercaptopurine UDP-glucuronosyl transferase Acetaminophen, tolbutamide, irinotecan | View Page |