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Phagocytic Information and Courses from MediaLab, Inc.

These are the MediaLab courses that cover Phagocytic and links to relevant pages within the course.

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Laboratories Individuals

CLIA Hematology / Hemostasis Review
Phagocytosis is a function of which of the following types of cells:View Page

Emerging Cardiovascular Risk Markers
Oxidized LDL Physiology

Oxidized LDL leads to the release of chemotactic factors from nearby cells; factors which signal leukocytes to migrate to the site. Recall that atherosclerosis is believed to be caused by phagocytic cells such as macrophages, which ingest LDL particles and turn into stationary foam cells. Macrophages have been shown to have increased affinity for oxidized LDL. Thus, oxidation makes LDL more susceptible to phagocytosis and therefore more atherogenic.Since oxidized LDL is more atherogenic than native LDL it makes sense that oxidized LDL may be a cardiovascular risk marker. Indeed, many studies have now correlated increased levels of oxidized LDL with risk of cardiac events.

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Normal Peripheral Blood Cells
Which type of leukocyte, transforms into a macrophage, has digestive enzymes within its granules and is phagocytic in tissues?View Page
Monocytes

Monocytes are phagocytes which remove injured and dead cells, cell fragments, microorganisms and insoluble particles from the blood and body tissues.Monocytes also secrete substances that affect the function of other cells, especially lymphocytes.They are produced in the bone marrow, and when mature are released into the peripheral blood. Although they do serve a phagocytic role in the blood, their main site of action is the body tissues.The half-life for monocytes in the peripheral blood is approximately 8 hours. Monocytes migrate into the tissues, often to sites of inflammation, where they serve their primary purpose.Here they transform into fixed or free macrophages, and continue their function as avid phagocytes.When activated, macrophages may enlarge and have enhanced metabolism.

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