Overdose Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Overdose and links to relevant pages within the course.
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| TDM for Theophylline Theophylline is used as a bronchodilator for treatment of moderate to severe asthma and chronic obstructive pulmonary disease (COPD). TDM is needed for theophylline because the kinetics of the drug are highly variable. It has a narrow therapeutic window, and overdose can result in elevated heart rate, arrhythmia, and CNS excitability. Clearance of the drug is increased in children, smokers, persons with cystic fibrosis, and persons with hyperthyroidism. Elimination is slowed in congestive heart failure and in the elderly. | View Page |
| TDM for Cardiac Medications Inotropics (drugs used to increase the pumping ability of the heart) and antiarrhythmics may need TDM. The cardiac glycoside inotropics digoxin and digitoxin have narrow therapeutic windows. Overdose can cause vomiting, diarrhea, confusion, visual disturbances, and cardiac arryhthmias. Examples of cardiac medications that are monitored by TDM include: Digoxin Digitoxin Procainamide N-Acetylprocainamide (NAPA) -the metabolite of procainamide Quinidine | View Page |