Myeloproliferative Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Myeloproliferative and links to relevant pages within the course.
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| The WBC indicated by the arrow in this illustration is exhibiting: | View Page |
| Pelger-Huet anomaly is characterized by: | View Page |
| Basophils in the Blood Basophils circulate in the blood for a short time and make up only a small percentage (0.5%) of the cells in circulation.They do not migrate to the tissues under normal conditions but may be seen when inflammation resulting from hypersensitivity to protein, contact allergy or skin allograft rejection is present.Basophils are sometimes increased in patients with chronic myeloproliferative disorders.
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| Howell -Jolly bodies/ other erythrocyte environmental alterations Several erythrocyte abnormalities are present in both the upper and lower photomicrographs. Many of these atypical cells are probably present as a result of the patient's splenectomy. Considerable anisocytosis and poikilocytosis with many tear-drop cells, bite cells, fragmented forms, and a few target cells are apparent. Some of the erythrocytes in the upper frame contain Howell-Jolly bodies (DNA fragments) that may be single or multiple, especially in myeloproliferative disorders. These inclusions stain negatively for iron and are eccentrically placed in the red cell cytoplasm. . | View Page |
| The large platelet captured in the center of the photograph is indicative of disordered megakaryopoiesis. | View Page |
| The peripheral blood smear tagged in the photograph was held for review because of too many platelets, about double the normal average of 8 - 15/oil immersion field or one per 10 - 20 RBC's. Conditions in which platelets are increased as noted in the photograph include: | View Page |
| The association of increased platelets accompanying neutrophilia and toxic granululation as illustrated in this photograph is called thrombocythemia. | View Page |
| The pale-staining cytoplasmic bodies marked by the arrow in the photograph may be seen in each of the following conditions except: | View Page |
| The granulated neutrophil shown in the photograph may be found in each of the following conditions except: | View Page |
| Eosinophil description The cytoplasm of eosinophils is evenly filled by numerous orange-red granules of uniform size. They do not overlie the nucleus.The eosinophil granules contain numerous enzymes including peroxidase, phospholipase D, catalase, acid phosphatase, and vitamin B12-binding proteins.Their ability to kill bacteria is less than that of neutrophils. Their main purpose is to counteract parasitic infections and to participate in immune allergic reactions.They may also be increased in a variety of nonimmunologic inflammatory responses from bacteria and fungi causing chronic infections. Malignancies, collagen vascular diseases, and myeloproliferative disorders may also may be settings for prominent eosinophils. | View Page |
| The neutrophils seen in two fields in the upper and lower photographs are representative of a majority of the left shift neutrophils found in this peripheral blood smear. The diagnosis of Pelger-Huet anomaly can be made. | View Page |
| Erythrophagocytosis Illustrated in the photograph is a phagocyte devouring several erythrocytes.This uncommon phenomenon occurs in the bone marrow and in the spleen as part of the process of erythrocyte destruction. Erythrophagocytosis is found in histological sections of the spleen in cases of hemolytic anemia.This phenomenon appears also in splenic sections in lupus erythematosis, and in rheumatoid arthritis.Our example is from a patient with a myeloproliferative disorder and is a rare example of a circulating erythrophagocytic cell in the peripheral blood. | View Page |